Senior Bioinformatics Engineer, Prenatal

BillionToOne (Headquarters: Menlo Park, CA or Remote)

Location: Menlo Park, CA   |   Full-Time   |   $156,060 - $176,868
Python Bioinformatics NGS Variant Filtering Visualization GitHub AWS PostgreSQL Data Engineer Staff Engineer

About BillionToOne: BillionToOne is a next-generation molecular diagnostics company with revolutionary QCT molecular counting technology that enhances disease detection resolution by over a thousandfold using cell-free DNA. Our products, like Unity Complete™, are transforming prenatal and oncology diagnostics by providing unprecedented accuracy and accessibility.

About The Role: We are looking for a Senior Bioinformatics Engineer to create computational tools that enable the analysis, interpretation, and reporting of ground-breaking molecular diagnostics data. You will be responsible for building bioinformatics pipelines, data analytics, interpretation tools, and automation needed to manage the generation, analysis, QC, and interpretation of clinical next-generation DNA sequencing data for our prenatal products.

Responsibilities:

  • Analyze and troubleshoot day-to-day operations for clinical NGS data analysis.
  • Build and maintain infrastructure and tools to support assay performance metrics.
  • Design and build new tools to scale and automate variant filtering, interpretation, and classification processes.
  • Collaborate and build microservice solutions with other clinically-oriented teams.
  • Support the development of sophisticated and robust NGS analysis pipelines.
  • Design and build new visualization tools to support clinical decisions.

Qualifications:

  • PhD in Bioinformatics, Biostatistics, Computational Biology, Computer Science, or other relevant field.
  • 3-5 years of biology or bioinformatics research experience.
  • 2-3 years of experience analyzing NGS data.
  • 1-2 years of full-stack software development experience.
  • Expertise in Python.
  • Experience with R or other programming languages used for data visualization.
  • Expertise with command-line tools and shell scripting within UNIX environments.

Benefits:

  • Base pay range of $156,060 - $176,868 per year.
  • Generous equity options offering.
  • Corporate bonus program.
  • Multiple medical benefit options with 100% premium coverage.
  • Generous Family Bonding Leave (16 weeks paid at 100%).
  • Free UNITY Complete NIPT testing for employees & spouses.
  • Retirement savings program with 4% Company match.
Post Date: August 18, 2025